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KMID : 0369820130430010063
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Jorunal of Korean Pharmaceutical Sciences
2013 Volume.43 No. 1 p.63 ~ p.69
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Biodegradable nanogel based on all-trans retinoic acid/pullulan conjugate for anti-cancer drug delivery
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Lee Ji-Eun
Jeong Doo-Yong
Seo Seog-Jin
Na Kun
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Abstract
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In order to improve the anticancer effect of drug, we designed and prepared biodegradable nanogel based on all-trans retinoic acid (ATRA)/pullulan conjugate (PURA). The nanogels have 47.19?38.24 % and 1.1?1.4 % of drug loading efficiency and drug contents, respectively. The controlled drug release and zero-order drug release behavior were shown for 10 days in the PURA nanogels. In the FACS data, the cellular uptake efficiency of doxorubicin (DOX) as an anti-cancer drug in PURA nanogel was similar with that of free DOX. DOX release from PURA nanogel was facilitated in cytosol due to and the polymer degradation. The cytotoxicity of PURA was restored by the polymer degradation up to that of free DOX as same concentration. Based on these, PURA nanogel has a possible potential for effective anticancer therapy.
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KEYWORD
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All-trans retinoic acid (ATRA), Doxorubicin (DOX), Pullulan, Nanogel, Controlled release
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